Document Type : Original Article

Authors

1 Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

3 Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

4 Shiraz HIV/AIDS Research Center, Institute of Health & Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran.

10.51757/IJEHS.4.2023.700773

Abstract

Introduction: Bloodstream infections (BSI) cause significant morbidity and mortality worldwide. Increasing Antimicrobial drug resistance among bacterial pathogens is an important issue of concern regarding appropriate therapeutic options. The aim of this study was to provide local information of resistance patterns to the commonly used antibiotics in Faghihi Hospital, Shiraz, Southwest Iran.

Methods: We studied the frequency and antibiogram patterns of blood culture bacterial isolates from 2018 to 2019. Antibacterial susceptibility testing was done by disk diffusion method, fulfilling the standard criteria of CLSI Performance Standards for Antimicrobial Susceptibility Testing 28th edition.

Result: From the total 5935 blood cultures during the study period, 576 (9.7%) were positive. From the total positive cultures, 340 (59.1%) were gram positive and 236 (40.9%) were gram negative bacteria. S.aureus was the most common isolate (26.2%) followed by S.epidermidis (15.1%) and E.coli (14.2%). The most effective antibiotic against gram positive bacteria was vancomycin, whereas we did not find a single antibiotic choice for gram negative bacteria. E.coli isolates where most susceptible to Amikacin and P.aeruginosa isolates to Imipenem.

Conclusion: Our findings suggest and emphasize the need to monitor blood cultures isolates and their susceptibility patterns yearly to observe resistance patterns affecting empirical therapy and infection control methods.

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