Pharmacoepidemiology
Calculation of non-inferiority margin in pharmacoepidemiology: Simple methods for clinicians

Kourosh Zali

Abstract
  The presence of a placebo arm is certainly a substantial element in randomized control trials (RCTs) because the effectiveness or efficacy of a new therapy can be evaluated through a direct comparison between the test treatment and the placebo arm. Conducting a placebo-controlled RCT is often very difficult ...  Read More

Pharmacoepidemiology
Non-inferiority trials and non-inferiority margin: an overview

Kourosh Zali

Volume 1, Continuous , 2020

https://doi.org/10.51757/IJEHS.1.4.2020.46956

Abstract
  The randomized controlled trial (RCT) is considered the best interventional design to assess issues related to treatment and prevention. The RCTs can have different designs including superiority, equivalence, or non-inferiority design. A superiority trial aims to detect the potential superiority of new ...  Read More