Epidemiology
Satvinder K Dhaliwal; Dana Dabelea; Angela E Lee-Winn; Deborah H Glueck; Greta Wilkening; Wei Perng
Abstract
Background: In utero exposure to increased inflammation caused by acute experiences may negatively impact on child neurodevelopment, but little is known about the effects of low-grade chronic inflammation. We wanted to investigate prenatal inflammation, as indicated by biomarkers of low-grade chronic ...
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Background: In utero exposure to increased inflammation caused by acute experiences may negatively impact on child neurodevelopment, but little is known about the effects of low-grade chronic inflammation. We wanted to investigate prenatal inflammation, as indicated by biomarkers of low-grade chronic inflammation, as an in utero programming method for neurodevelopment, and see how much of these associations are explained by perinatal factors. Methods: We utilized linear regression to analyze the relationship between prenatal C-reactive protein, interleukin-6, and tumor necrosis factor-α and offspring Child Behavior Check List scores for total problems, externalizing and internalizing behaviors in 489 mother-offspring pairs from the Healthy Start cohort, based in Denver, Colorado, USA. We made sequential adjustments for perinatal correlates. Model 1 considered maternal age, gestational age at blood draw, and child age. Model 2 included further adjustments for mother race/ethnicity, followed by household income in Model 3 and pre-pregnancy body mass index (BMI) in Model 4. Finally, we used the maternal Edinburgh Postnatal Depression Scale and Perceived Stress Scale scores as measures of psychosocial stress. Results: In Model 1, children of mothers with C-reactive protein in the fourth quartile had a 3.82 (95% CI: 0.94, 6.70) unit higher t-score for total problems compared to those in the first to third quartiles. The inclusion of household income and pre-pregnancy BMI in the fully adjusted model reduced the impact estimate to 3.11 (-0.45, 6.67). We found a similar pattern in externalizing behavior and across models for interleukin 6. Conclusions: Maternal inflammation is associated with worse neurobehavioral outcomes in children. This association was influenced by higher pre-pregnancy BMI and lower household income.
COVID-19
Joseph Oyepata Simeon; Joseph Opeyemi Tosin
Abstract
Retracted article
Background and Objective: Scientists and world leaders are still trying to understand COVID-19 and its potential global consequences. While there have been some successes, there are still many that remain unknown. This study provides an update report on the virological and immunological ...
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Retracted article
Background and Objective: Scientists and world leaders are still trying to understand COVID-19 and its potential global consequences. While there have been some successes, there are still many that remain unknown. This study provides an update report on the virological and immunological distribution and implications of the COVID-19 pandemic around the world from January 28th to February 3rd, 2022..Material and Method: The United Nations geoscheme was used to obtain data from 196 countries and regions around the world. The results were compiled and compared to the values obtained for the United States.Results: When available data was compared to that of the United States, the American continent had a higher mortality comparison factor than infection cases, whereas the European continents had a higher infectious comparison value than mortality value. With the exception of South Africa and Botswana, the African continents appear unconcerned about the value of mortality and infectivity.Conclusion: The new wave and virus variant have caused a resurgence in its global impact. There is a need to understand how Africa has survived all variants of the virus despite having few medical resources.
COVID-19
Joseph Oyepata Simeon; Joseph Opeyemi Tosin; Sabastine Aliyu Zubairu
Abstract
Background and Objective: COVID-19 has had a worldwide impact in a variety of ways since its discovery in China. As a result, it's critical to maintain a constant eye on the virus's impact around the world. The goal of this research is to compile a global assessment of COVID-19 demographics and distribution, ...
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Background and Objective: COVID-19 has had a worldwide impact in a variety of ways since its discovery in China. As a result, it's critical to maintain a constant eye on the virus's impact around the world. The goal of this research is to compile a global assessment of COVID-19 demographics and distribution, as well as a COVID-19 update report till February 17th, 2022.Methods: Data was provided by the United Nations Geochem database from 151 nations and areas throughout the world. The results were compiled and compared to the figures obtained for the United States.Result: When compared to the United States, the American continent has a lower incidence but the same fatality rate. When compared to the United States, most European and Asian countries have the same cumulative incidence and mortality rates as the United States, except for a few countries such as the United Kingdom and the Netherlands. When compared to the United States, the African continent has an extremely low incidence and fatality rate.Conclusion: The development of the Omicron variety seems to make COVID-19's approach and comprehension more complicated. As a result, the virus has had a long-term impact all over the world. Africa, on the other hand, is not particularly afflicted by all the virus's strains. As a result, the rest of the world must research the cause of this "African exception" and maybe comprehend its ramifications in terms of potential immunity.
