Cancer Screening
Fatih Kara; Bekir Keskinkilic; Murat Turkyilmaz; Fahriye Unlu; Selin Dundar; Erkin Aribal; Serap Gultekin; Aysenur Oktay
Abstract
Introduction: In Turkey, a population-based breast cancer screening program for women aged 40 to 69 years old was recently introduced. The goal of this study was to document early outcomes and assess the program's success.Method: This study looked at the 348,638 women who were screened in 2016. For end ...
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Introduction: In Turkey, a population-based breast cancer screening program for women aged 40 to 69 years old was recently introduced. The goal of this study was to document early outcomes and assess the program's success.Method: This study looked at the 348,638 women who were screened in 2016. For end results, all data was gathered from the national centralized reporting system and the Cancer Registry database. For benign discoveries, Breast Imaging-Reporting and Data System (BI-RADS) 1-2 were applied, and for recalls, BI-RADS 0, 4, or 5 were utilized, depending on the level of suspicion. The study looked at the age distribution, recall rate, cancer detection, and interval cancer rates. The stages of identified malignancies were examined and compared to those of the nonscreened group throughout the same time frame.Results: In the screening population, 43.2 percent of women were between the ages of 40 and 49, and 56.8% were between the ages of 50 and 69. The age range of 50–69 was responsible for 70% of screen-detected malignancies. The total recall rate (n = 19,607) was 5.6 percent. The malignancy rate for BI-RADS 5 recalls was 70.2 percent, 19.2 percent for BI-RADS 4, and 1.7 percent for BI-RADS 0 recalls. Screen-discovered malignancies were detected at a rate of 3.2 per 1000 screening exams (n = 1,120). When compared to the Non screened group, the screened group had a larger percentage of early-stage illness (54.3%). (46.7 percent). Interval cancers were discovered in 231 women (0.66 per 1000 screened women).Conclusion: Turkey's recently launched population-based breast cancer screening program appears to be viable and successful, according to preliminary results. According to this study, the breast cancer screening program should be sustained, with coverage of the target group rising.
Clinical Epidemiology
F. Aliakbari; F. Safei; F. Deriss; S. Salehitali
Abstract
Introduction: Patients with chronic renal disease are at risk for dyspnea, which can have a negative impact on their quality of life. The current study aims to investigate the influence of breathing exercise on respiratory parameters in hemodialysis patients due to a lack of agreement on the efficacy ...
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Introduction: Patients with chronic renal disease are at risk for dyspnea, which can have a negative impact on their quality of life. The current study aims to investigate the influence of breathing exercise on respiratory parameters in hemodialysis patients due to a lack of agreement on the efficacy of breathing exercise in the respiratory status of hemodialysis patients.Method: Participants were randomly assigned to one of two groups in this single-blind clinical investigation (intervention and control). Under the supervision of a nurse, the intervention group practiced breathing interventions (deep and slow breathing) for eight sessions over the course of a month. Data was collected using two questionnaires (demographic and respiratory parameter checklist).Results: There was a significant change (P=0.000) between the pre- and post-scores of the respiratory score in the intervention and control groups.Conclusion: Because breathing intervention is beneficial in lowering dyspnea and improving respiratory parameters, nurses should consider using it as an appropriate therapy for these patients due to its simplicity and low cost.
COVID-19
Samira Zouhri; Mohcine El Baroudi
Abstract
A woman in her sixties with a normal medical history was admitted to a general medical floor with Neuropathic pain symptoms such as a burning sensation throughout her body (head, back, spine, throat, and tongue with dry mouth, chest, abdomen, kidneys, thighs, toes), inability to eat, urinary incontinence, ...
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A woman in her sixties with a normal medical history was admitted to a general medical floor with Neuropathic pain symptoms such as a burning sensation throughout her body (head, back, spine, throat, and tongue with dry mouth, chest, abdomen, kidneys, thighs, toes), inability to eat, urinary incontinence, difficulty wearing clothing, and difficulty leaning on the back. There was a difficulty and delay in diagnosing the patient's condition, which was confirmed to have severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with no respiratory symptoms. The patient's pain did not respond to the covid-19's first-line medications, but it did respond to neuropathic medication with Pregabalin and Alprazolam. Our study shows that Pregabalin could be helpful in relieving the patient’s pain and very effective for treating neuropathic pain with a safe profile, unlike Alprazolam, which interferes with the same stages of sleep, which made her sleep condition worse.
Clinical Epidemiology
Farshad Kakian; Mohammad Ghasemi Palangi; Nahal Hadi
Abstract
Background: Urinary stones are one of the major health problems worldwide and a significant part of referrals to physicians. Also, growing antibiotics resistance is an important concern. The purpose of this study was to evaluate the prevalence of urinary stones and bacterial strains with antibiotic resistance ...
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Background: Urinary stones are one of the major health problems worldwide and a significant part of referrals to physicians. Also, growing antibiotics resistance is an important concern. The purpose of this study was to evaluate the prevalence of urinary stones and bacterial strains with antibiotic resistance in women admitted to shiraz, southwest of Iran, from 2014 to 2019. Methods: In this period, all women admitted to the Zeinabieh Hospital were evaluated. The frequency of urinary stones and bacterial strains and antibiogram patterns of bacterial isolates were investigated from 2014 to 2019.Antibacterial susceptibility testing was done by disk diffusion method, fulfilling the standard criteria of “Clinical and Laboratory Standards Institute (CLSI) Performance Standards for Antimicrobial Susceptibility”. Results: Out of 101 isolates, the identified gram-negative bacteria were E. coli (68.3%), Klebsiella (6.9%), Enterobacter (6.9%), Pseudomonas (5%), Proteus (1%), and Acinetobacter (1%). Of gram-positive strains, Coagulase-positive Staphylococci (5.9%), coagulase-negative Staphylococcus (CONS) (3%) and Non-Hemolytic Streptococci (2%) were identified. Also, the frequency of urinary tract stones was about 5%. Four cases of kidney stones were associated with E. coli and one case with Klebsiella. All isolates had the highest resistance to co-trimoxazole (62.5%), Ampicillin and Nalidixic acid.Conclusion: In this study, no association was found between the type of bacteria and urinary stone. From the variable bacteria isolated, the highest rate of E. coli (as an important pathogen) was confirmed. Also, most of the bacterial isolates were resistant to multiple antibiotics, although Amikacin and nitrofurantoin (as the empirical therapy in our hospital) were dominated.
COVID-19
Jose Luis Turabian
Abstract
BackgroundMost people with COVID-19 receive care at home, increasing the likelihood of exposure for household members.ObjectiveTo study the prevalence and characteristics of secondary cases in families after the appearance of a primary caseMethodologyAn observational and retrospective study of families ...
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BackgroundMost people with COVID-19 receive care at home, increasing the likelihood of exposure for household members.ObjectiveTo study the prevalence and characteristics of secondary cases in families after the appearance of a primary caseMethodologyAn observational and retrospective study of families with at least one polymerase chain reaction (PCR) confirmed COVID-19 primary case was conducted from March 15 to December 25, 2020, in a general medicine office in Toledo, Spain. Socio-demographic and clinical variables were compared between primary and secondary cases in the families. The outcome of interest was secondary attack rate of SARS-CoV-2 within the family.Results39 families with a primary case (average size 3.4 members) with a total of 132 cohabitants were included. There were 22 cohabitants with negative PCR (22/92 = 24%), 70 secondary cases with positive PCR (Secondary attack rate 76%), of which 25 were asymptomatic (25/70 = 36%), and a cohabiting new-born. A high frequency of people from ethnic minorities, low household income and complex families was found, both in primary and secondary cases. The secondary cases with respect to the primary ones were more women, younger, students and with a lower socio-occupational level, with more asymptomatic cases, and milder symptomatic cases.ConclusionsIn this context, the prevalence of secondary domestic contacts is very high, and it occur in young women, being asymptomatic or mild. The high secondary attack rate suggests the importance of the pre-symptomatic or early symptomatic period of COVID-19, as well as the possible failure to comply with isolation measures.
Occupational Epidemiology
Amanuel Godana Arero; Godana Arero; Shimels Hussien Mohammed; Sahar Eftekhari
Abstract
Background and objective: Low back pain (LBP), as a musculoskeletal disorder, remains a common health problem and is one of the most prevalent occupational injuries affecting adults living in both developed and developing countries. To increase the power and improve the prevalence estimates of LBP among ...
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Background and objective: Low back pain (LBP), as a musculoskeletal disorder, remains a common health problem and is one of the most prevalent occupational injuries affecting adults living in both developed and developing countries. To increase the power and improve the prevalence estimates of LBP among the working Ethiopian population, a comprehensive meta-analysis was carried out. Methods: A comprehensive systematic literature search was conducted through multiple international electronic bibliographic databases such as Web of Science, Pub Med, EMBASE, Scopus, and Google Scholar. Population-based studies with the prevalence of LBP among the working population living in Ethiopia were included. Meta-analyses, meta-regression, and sensitivity analysis was conducted. Funnel plot symmetry visualization followed by Begg’s rank correlation, and Egger’s regression asymmetry test methods were performed to detect the existence of publication bias. Heterogeneity between studies was assessed by using the Cochrane Q and I2 statistics. Results: Overall, 719 articles were identified and 13 articles with 6513 participants met the inclusion criteria for meta-analyses. The pooled point and twelve-month prevalence of LBP among the working Ethiopian population was 49% (95% CI: 40-58) and 56% (95% CI: 49-62), respectively. Conclusion: The results showed a high prevalence of LBP among the working Ethiopian population, especially among teachers. We believe that prevention strategies addressing the early onset of LBP among the working population would most likely be the answer to the burden of LBP on future economies in Ethiopia.
Molecular Epidemiology
Farshad Kakian; Mohammad hoseein Rezaei; Masoud Amiri; saeid janabadi; behnam zamanzad; Abolfazle gholipour; Kourosh Naderi
Abstract
Background and aim: Klebsiella is an opportunistic organism that is the cause of many nosocomial infections. The present study was designed to investigate the molecular epidemiology of Verona integron-encoded metallo-β-lactamase (VIM) and Imipenemase (IMP)-producing Klebsiella isolates in ...
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Background and aim: Klebsiella is an opportunistic organism that is the cause of many nosocomial infections. The present study was designed to investigate the molecular epidemiology of Verona integron-encoded metallo-β-lactamase (VIM) and Imipenemase (IMP)-producing Klebsiella isolates in patients with urinary tract infection (UTI) in an educational hospitalin Shahrekord, in the center of Iran. Methods: In a cross-sectional study, from 234 urine samples, 80 isolates of Klebsiella were identified with biochemical tests. In order to determine the production of Metallo-β-lactamases (MBLs), Modified Hodge Test (MHT), EDTA Disc Synergy (EDS) test and AmpC disc test were performed. The frequency of VIM and IMP genes was determined after DNA-amplification with PCR by electrophoresis technique. Thereby, 16SrRNA was considered as an internal control in PCR.Results: Phenotypic tests showed that out of the 80 isolates, 18 (22. 5%), 18 (22. 5%) and 10 (12.5%) isolates were positive for MHT, EDS and AmpC disc test, respectively. Following DNA amplification by PCR, the genes of interest were analyzed by electrophoresis technique. The findings were as follows: 22 isolates (27.5%) carried the VIM gene, but the IMP gene was not found in any of the isolates. Conclusions: Expansion of Klebsiella strains that produce MBLs is a severe threat to health centers and public health. The findings of this study showed that Klebsiella may produce MBLs. These enzymes can in turn degrade carbapenem antibiotics, which are considered as a last resort in the treatment of multidrug-resistant (MDR) infections.
