COVID-19
Jose Luis Turabian
Abstract
Background: Longitudinal data on SARS-CoV-2 re-infection are scarce. Objectives: 1) Characterize COVID-19 reinfection cases clinically and epidemiologically; 2) Determine whether the risk of SARS-CoV-2 reinfection has altered over time in the context of the development of beta, delta, and omicron ...
Read More
Background: Longitudinal data on SARS-CoV-2 re-infection are scarce. Objectives: 1) Characterize COVID-19 reinfection cases clinically and epidemiologically; 2) Determine whether the risk of SARS-CoV-2 reinfection has altered over time in the context of the development of beta, delta, and omicron variants.Methods: From March 1, 2020 to July 1, 2022, an observational, longitudinal, and prospective investigation of Covid-19 re-infections was done in a general medical practice in Toledo, Spain.Results: There were 43 cases in total, including 45 reinfections (2 cases presented 2 reinfections). The average period between first infection and reinfection was 346 days (range: 95-813 days). The average age was 41 years (range: 17-70 years). 5% were over the age of 65. 56% were female. 14% belonged to an ethnic minority. 82% of reinfections occurred among individuals who had been vaccinated (19%, 28%, and 35% in those who had received one dose, two doses, and a booster, respectively). They were symptomatic in 96% of the cases. All cases of reinfection were minor, with nonspecific symptoms (discomfort, asthenia, myalgia, fever, arthralgia) predominating (39%). Chronic illnesses were present in 60% of reinfection cases, with the Genitourinary (19%), Endocrine (17%), and Respiratory (16%) systems predominately. Reinfections have been steadily growing since 2020, with 67% occurring in 2022.Conclusion: We discovered evidence of a continual increase in the incidence of reinfections in Toledo, Spain, primarily beginning in January 2022, which is temporally congruent with the introduction of the omicron variety, indicating its improved ability to infect previously infected persons.
COVID-19
Jose Luis Turabian
Abstract
Background: It's unclear whether vaccination individuals against SARS-CoV-2 protects family members in the same way. Objective: The assessment of risk factors for SARS-CoV-2 transmission from index cases with COVID-19 breakthrough infection in completely vaccinated patients to fully vaccinated family ...
Read More
Background: It's unclear whether vaccination individuals against SARS-CoV-2 protects family members in the same way. Objective: The assessment of risk factors for SARS-CoV-2 transmission from index cases with COVID-19 breakthrough infection in completely vaccinated patients to fully vaccinated family members. Methods: From February 1 to November 30, 2021, an observational, longitudinal, and prospective research of families with one primary case of COVID-19 breakthrough infection was done in a general medicine practice in Toledo, Spain.Results: Thirteen primary cases of COVID-19 breakthrough infection in 13 families with at least one other family member were included, of which 9 were positive secondary cases (sick) and 8 were negative partners (healthy) properly vaccinated. Being a woman, being over 45 years old, being a social-health professional, being an ethnic minority, and having chronic conditions all increased the likelihood of developing COVID-19 in fully vaccinated contacts and main cases. Although vaccination 2ChAdOx1 nCoV-19 had a higher effectiveness than BNT162b2 mRNA, none of these risk or protective factors were statistically significant.Conclusion: Young women, social health workers, ethnic minority groups, and people with chronic diseases are the completely vaccinated contacts with the highest risk of having COVID-19, after primary cases also vaccinated in the family, in Toledo (Spain), when the delta variant became dominant but before the rise of omicron.
COVID-19
Jose Luis Turabian
Abstract
BackgroundMost people with COVID-19 receive care at home, increasing the likelihood of exposure for household members.ObjectiveTo study the prevalence and characteristics of secondary cases in families after the appearance of a primary caseMethodologyAn observational and retrospective study of families ...
Read More
BackgroundMost people with COVID-19 receive care at home, increasing the likelihood of exposure for household members.ObjectiveTo study the prevalence and characteristics of secondary cases in families after the appearance of a primary caseMethodologyAn observational and retrospective study of families with at least one polymerase chain reaction (PCR) confirmed COVID-19 primary case was conducted from March 15 to December 25, 2020, in a general medicine office in Toledo, Spain. Socio-demographic and clinical variables were compared between primary and secondary cases in the families. The outcome of interest was secondary attack rate of SARS-CoV-2 within the family.Results39 families with a primary case (average size 3.4 members) with a total of 132 cohabitants were included. There were 22 cohabitants with negative PCR (22/92 = 24%), 70 secondary cases with positive PCR (Secondary attack rate 76%), of which 25 were asymptomatic (25/70 = 36%), and a cohabiting new-born. A high frequency of people from ethnic minorities, low household income and complex families was found, both in primary and secondary cases. The secondary cases with respect to the primary ones were more women, younger, students and with a lower socio-occupational level, with more asymptomatic cases, and milder symptomatic cases.ConclusionsIn this context, the prevalence of secondary domestic contacts is very high, and it occur in young women, being asymptomatic or mild. The high secondary attack rate suggests the importance of the pre-symptomatic or early symptomatic period of COVID-19, as well as the possible failure to comply with isolation measures.
