Document Type : Original Article
- Farshad Kakian 1
- Arman Jobeiri 2
- Zahra Hashemizadeh 1
- Babak Shirazi Yeganeh 3
- Mohammad Motamedifar 4
1 Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
3 Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4 Shiraz HIV/AIDS Research Center, Institute of Health &amp;amp;amp;amp;amp; Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran.
Introduction: Bloodstream infections (BSI) are a leading cause of morbidity and mortality around the world. In terms of appropriate therapeutic options, antimicrobial drug resistance among bacterial pathogens is a major source of concern. The purpose of this study was to provide local information on antibiotic resistance patterns in Faghihi Hospital located in Shiraz, Southwest Iran.
Methods: The frequency and antibiogram patterns of blood culture bacterial isolates were studied from January 2018 to December 2019. For antibacterial susceptibility testing, the disk diffusion method was used, which met the standard criteria of the Clinical and Laboratory Standards Institute (CLSI) Performance Standards for Antimicrobial Susceptibility Testing 28th edition.
Results: During the study period, 576 (9.7%) of the 5935 blood cultures tested positive. Gram positive bacteria made up 340 (59.1%) of the positive cultures, while gram negative bacteria made up 236 (40.9%). S. aureus was the most common isolate (26.2%), followed by S. epidermidis (15.1%) and E. coli (14.2%). Vancomycin was the most effective antibiotic against gram positive bacteria, but no antibiotic was available for gram negative bacteria. Amikacin was most effective against E. coli isolates, while Imipenem was most effective against P. aeruginosa isolates.
Conclusion: Our findings suggest and emphasize the importance of observing resistance patterns that affect empirical therapy and infection control methods on a yearly basis by monitoring blood culture isolates and susceptibility patterns.