Background: Ulcer caused by Helicobacter pylori has been of major public health concern due to its persistence. This study was carried out to evaluate the effects of some risk factors on the incidence of Helicobacter pylori infection among patients with peptic ulcer attending health facilities in Lafia, Nigeria.
Methods: The blood and stool samples of 180 participants (71 males and 109 females) were randomly collected and screened using H. pylori antibody/ antigen test strips (Azure Biotech Inc) and the stool also cultured on Columbia blood agar base (TITAN Biotech Ltd). Some risks information on the participants were also collected using a structured questionnaire.
Results: Out of the 71 male and 109 female subjects tested, 14/71 (19.72%) and 37/109 (33.94%) tested positive for culture method (CM) respectively. Occurrence of Helicobacter pylori infection was found to be significantly higher (p=0.038) among female participants than their male counterparts for CM only. However, age groups were found to have no significant difference (p>0.05) using all analytical methods. Married subjects had significantly higher incidence (p=0.021) for blood antibody (BAB) method only with 79/116 (68.10%) reactive cases. Other factors were shown to serve as possible risks for H. pylori infection with Drinking water source (p <0.001, 0.16, 0.017 using CM, BAB and SAG respectively) and number of occupants per room (p = <0.001, <0.001, 0.002 using CM, BAB and SAG respectively) having significant difference using all analytical methods.
Conclusion: Most risk factors considered for this research had significant association with Helicobacter pylori infection in Lafia, Nigeria.